Format

Send to

Choose Destination
J Antibiot (Tokyo). 1997 Jul;50(7):543-5.

Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: structural elucidation.

Author information

1
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.

Abstract

Lymphostin (LK6-A), a novel immunosuppressant, was isolated from the culture broth of Streptomyces sp. KY11783. Lymphostin showed potent inhibitory activity against the lymphocyte kinase, Lck (p56lck). The structure of lymphostin was determined by spectroscopic methods to be a novel tricyclic aromatic alkaloid. A key feature of the structure is the pyrrolo[4,3,2-de]quinoline moiety which is rare among natural products.

PMID:
9711244
DOI:
10.7164/antibiotics.50.543
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center