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Curr Opin Genet Dev. 1993 Jun;3(3):398-403.

Trisomy in humans: incidence, origin and etiology.

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Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106.


Molecular studies conducted over the past year have demonstrated the importance of aberrant genetic recombination in the etiology of several human trisomies, and have begun to shed light on the basis of the association between advancing maternal age and trisomy. Preliminary studies of gametes using fluorescence in situ hybridization indicate that this will be a useful approach in the analysis of human non-disjunction.

[Indexed for MEDLINE]

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