Send to

Choose Destination
Ther Drug Monit. 1993 Jun;15(3):247-50.

Carbamazepine coadministration with fluoxetine or fluvoxamine.

Author information

Institute of Pharmacology, University of Messina, Italy.


To study the potential interaction between carbamazepine (CBZ) and selective serotonin reuptake inhibitors, fluoxetine (20 mg/day) and fluvoxamine (100 mg/day) were administered for 3 weeks to eight and seven epileptic patients, respectively, on chronic CBZ treatment. No significant changes in steady-state plasma concentrations of CBZ and its active metabolite, carbamazepine-10,11-epoxide (CBZ-E) occurred, suggesting that CBZ metabolism is probably not affected by fluoxetine or fluvoxamine administration.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center