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In Vivo. 2010 Sep-Oct;24(5):687-94.

Certain surfactants show promise in the therapy of pulmonary tuberculosis.

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  • 1UT-Houston Medical School, 6431 Fannin St., Houston, TX 77030, USA. james.k.stoops@uth.tmc.edu

Abstract

BACKGROUND/AIM:

The aim of the present study was to develop the basis for the use of surfactants in the treatment of pulmonary tuberculosis (TB). Bacteria are surrounded by a thick lipid coat primarily consisting of trehalose dimycolate (TDM) and, consequently, are well shielded from the immune system's response and antibiotics. This protective barrier was removed by exposing the bacteria to certain surfactants.

MATERIALS AND METHODS:

Dodecyl maltoside (DDM) and octyl glucoside (OG) were utilized as non-toxic surfactants.

RESULTS:

Electron microscopy (EM) studies revealed that aggregated bacteria were also covered with excessive TDM which exacerbate the treatment efforts. Light and EM studies demonstrated that DDM and OG disperse the aggregated bacteria and are bactericidal.

CONCLUSION:

The studies presented here establish that certain surfactants are proficient in removing MTB's shield and, because they are well known as cell permeabilizing agents, they may also enhance the effectiveness of antibiotics and the immune system's response in the treatment of pulmonary TB.

PMID:
20952734
[PubMed - indexed for MEDLINE]

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