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Philos Trans R Soc Lond B Biol Sci. 2017 May 26;372(1721). pii: 20160297. doi: 10.1098/rstb.2016.0297.

The Ebola outbreak, 2013-2016: old lessons for new epidemics.

Author information

1
Research Department of Infection and Population Health, UCL, London WC1E 6JB, UK cordelia.coltart@ucl.ac.uk.
2
Chatham House, London SW1Y 4LE, UK.
3
Research Department of Infection and Population Health, UCL, London WC1E 6JB, UK.
4
London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

Abstract

Ebola virus causes a severe haemorrhagic fever in humans with high case fatality and significant epidemic potential. The 2013-2016 outbreak in West Africa was unprecedented in scale, being larger than all previous outbreaks combined, with 28 646 reported cases and 11 323 reported deaths. It was also unique in its geographical distribution and multicountry spread. It is vital that the lessons learned from the world's largest Ebola outbreak are not lost. This article aims to provide a detailed description of the evolution of the outbreak. We contextualize this outbreak in relation to previous Ebola outbreaks and outline the theories regarding its origins and emergence. The outbreak is described by country, in chronological order, including epidemiological parameters and implementation of outbreak containment strategies. We then summarize the factors that led to rapid and extensive propagation, as well as highlight the key successes, failures and lessons learned from this outbreak and the response.This article is part of the themed issue 'The 2013-2016 West African Ebola epidemic: data, decision-making and disease control'.

KEYWORDS:

Ebola; Ebola outbreak; Ebola virus disease; West Africa

PMID:
28396469
PMCID:
PMC5394636
DOI:
10.1098/rstb.2016.0297
[Indexed for MEDLINE]
Free PMC Article

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