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BMJ. 2004 Jun 12;328(7453):1405. Epub 2004 May 14.

Long term follow up study of survival associated with cleft lip and palate at birth.

Author information

1
Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, DK-5000 Odense, Denmark. kchristensen@health.sdu.dk

Abstract

OBJECTIVE:

To assess the overall and cause specific mortality of people from birth to 55 years with cleft lip and palate.

DESIGN:

Long term follow up study.

SETTING:

Danish register of deaths.

PARTICIPANTS:

People born with cleft lip and palate between 1943 and 1987, followed to 1998.

MAIN OUTCOME MEASURES:

Observed and expected numbers of deaths, summarised as overall and cause specific standardised mortality ratios.

RESULTS:

5331 people with cleft lip and palate were followed for 170 421 person years. The expected number of deaths was 259, but 402 occurred, corresponding to a standardised mortality ratio of 1.4 (95% confidence interval 1.3 to 1.6) for males and 1.8 (1.5 to 2.1) for females. The increased risk of mortality was nearly constant for the three intervals at follow up: first year of life, 1-17 years, and 18-55 years. The participants had an increased risk of all major causes of death.

CONCLUSIONS:

People with cleft lip and palate have increased mortality up to age 55. Children born with cleft lip and palate and possibly other congenital malformations may benefit from specific preventive health measures into and throughout adulthood.

PMID:
15145797
PMCID:
PMC421777
DOI:
10.1136/bmj.38106.559120.7C
[Indexed for MEDLINE]
Free PMC Article

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