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Mycopathologia. 2019 Oct 15. doi: 10.1007/s11046-019-00388-x. [Epub ahead of print]

Molecular Typing of Candida glabrata.

Author information

1
Comparative Genomics Group, Life Science Programme, Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain.
2
Institute of Research in Biomedicine (IRB), Barcelona, Spain.
3
Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain.
4
Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, 37075, Göttingen, Germany.
5
Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, 37075, Göttingen, Germany. obader@gwdg.de.

Abstract

The yeast Candida glabrata has emerged, second only to Candida albicans, to be one of the most frequently isolated fungi in clinical specimen from human. Its frequent resistance towards azole antifungal drugs and the high capacity to form biofilms on indwelling catheters of individual isolates render it an often difficult to treat pathogen. Hence, there is a notably increasing scientific and clinical interest in this species. This has led to the development of a variety of molecular tools for genetic modification, strain collections, and last but not least different approaches to analyse the population structure among isolates of different geographical and clinical contexts. Often, these are used to study correlations (or the absence thereof) with different pathogenicity, virulence, or drug resistance traits. Three molecular methods have been used to type within the C. glabrata population on a genetic level by multiple studies: multi-locus sequence typing, microsatellite length polymorphisms, and clustering of whole-genome sequencing data, and these are subject of this review.

KEYWORDS:

Candida glabrata; Microsatellite typing (MLP); Multi-locus sequence typing (MLST); Whole-genome sequencing (WGS); pubmlst.org

PMID:
31617105
DOI:
10.1007/s11046-019-00388-x

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