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Mol Cell Oncol. 2019 Jun 24;6(5):e1632687. doi: 10.1080/23723556.2019.1632687. eCollection 2019.

TP53INP2 at the crossroad of apoptosis and autophagy in death receptor signaling.

Ivanova S1,2,3, Zorzano A1,2,3.

Author information

1
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
2
CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain.
3
Departament de Bioquimica i Biomedicina Molecular, Universitat de Barcelona, Barcelona, Spain.

Abstract

The binding of ligands to death receptors elicits distinct outcomes, such as apoptosis, inflammation and necroptosis, depending on the cellular context. We have recently described that the autophagic protein TP53INP2 favors apoptosis upon death receptor signaling and is a potential biomarker of responsiveness to TRAIL treatment.

KEYWORDS:

TP53INP2; TRAIL; apoptosis; autophagy; death receptor signaling

PMID:
31528702
PMCID:
PMC6736201
[Available on 2020-06-24]
DOI:
10.1080/23723556.2019.1632687

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