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Genes Dev. 2019 Sep 1;33(17-18):1095-1097. doi: 10.1101/gad.330530.119.

Nxf3: a middleman with the right connections for unspliced piRNA precursor export.

Author information

1
Department of Molecular Biology, Science III, University of Geneva, CH-1211 Geneva 4, Switzerland.

Abstract

RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208-1220) identify Nxf3 as a novel germline-specific export adapter for such unspliced transcripts. Their findings reveal the sequence of events leading from its role at the site of transcription to delivery of the cargo to cytoplasmic piRNA biogenesis sites.

KEYWORDS:

PIWI proteins; RNA export; nuclear export factor; piRNA clusters; transposon control

PMID:
31481534
PMCID:
PMC6719615
[Available on 2020-03-01]
DOI:
10.1101/gad.330530.119

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