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Mol Cell. 2019 Aug 8;75(3):417-418. doi: 10.1016/j.molcel.2019.07.019.

Manipulation by Methylation: Garnishing mRNAs with m6Am.

Author information

1
Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2
Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: yunsun.nam@utsouthwestern.edu.

Abstract

In two recent publications in Molecular Cell,Boulias et al. (2019) and Sendinc et al. (2019) use complementary approaches to map m6Am modification sites transcriptome-wide and demonstrate that m6Am can repress translation while increasing the stability of a subset of low-abundance transcripts.

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