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Cell. 2019 Jul 25;178(3):515-517. doi: 10.1016/j.cell.2019.07.006.

Counting the Cuts: MAZTER-Seq Quantifies m6A Levels Using a Methylation-Sensitive Ribonuclease.

Author information

1
Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
2
Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland. Electronic address: ramesh.pillai@unige.ch.

Abstract

Garcia-Campos et al. describe MAZTER-seq, which deploys a sequence-specific, methylation-sensitive bacterial single-stranded ribonuclease MazF to provide nucleotide-resolution quantification of m6A methylation sites. The study reveals many new sites and supports the idea of a predictable "m6A code," where methylation levels are dictated primarily by local sequence at the site of methylation.

PMID:
31348883
DOI:
10.1016/j.cell.2019.07.006

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