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Angew Chem Int Ed Engl. 2019 Jul 16. doi: 10.1002/anie.201906633. [Epub ahead of print]

Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII -Catalyzed Three-Component C-H Bond Addition to Internally Substituted Dienes and Carbonyls.

Author information

1
Department of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.

Abstract

An efficient CoIII -catalyzed three-component strategy to prepare homoallylic alcohols containing acyclic quaternary centers is disclosed. This transformation enables the introduction of two C-C σ bonds through C-H bond activation and sequential addition to internally substituted dienes and a wide range of aldehydes and activated ketones. Isoprene and other internally monosubstituted dienes are effective inputs, with the reaction proceeding with high diastereoselectivity for those substrate combinations that result in more than one stereogenic center. Moreover, the opposite relative stereochemistry can be achieved by employing 1,2-disubstituted dienes. A mechanism for the transformation is proposed based upon the relative stereochemistry of the products and studies with isotopically labeled starting materials.

KEYWORDS:

C−H activation; cobalt; diastereoselectivity; homogeneous catalysis; multicomponent reactions

PMID:
31310435
DOI:
10.1002/anie.201906633

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