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J Pediatr Hematol Oncol. 2019 Jun 27. doi: 10.1097/MPH.0000000000001544. [Epub ahead of print]

Sustained Remission After Maintenance Irinotecan in Patient With Multiply Relapsed Hepatoblastoma.

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Byramjee JeejeeBhoy Medical College, Pune, Maharashtra, India.
Department of Pediatrics, Yale University School of Medicine, CT.


Children with recurrent hepatoblastoma have a poor prognosis and limited treatment options. The authors describe a child with metastatic hepatoblastoma who had multiple relapses. He was treated with surgical resection and adjuvant chemotherapy at first relapse. At second relapse, he had progressive disease postresection. He was treated with ifosfamide/carboplatin/etoposide chemotherapy followed by maintenance irinotecan and achieved long-term disease-free survival. Irinotecan as maintenance should be explored in recurrent hepatoblastoma.

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