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Curr Opin Struct Biol. 2019 Jun 25;58:88-96. doi: 10.1016/j.sbi.2019.05.016. [Epub ahead of print]

First-generation predictors of biological protein phase separation.

Author information

1
Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
2
Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: forman@sickkids.ca.

Abstract

Biological condensates, including membraneless organelles, can consist of hundreds of proteins, and it is important to identify which proteins are driving condensation and which proteins have evolved to regulate protein compartmentalization by liquid-liquid phase separation. Predictors that have been used for this purpose have emerged from a variety of perspectives and have diverse designs, sequence dependencies, and physical bases. Here, we describe, compare, and contrast a range of first-generation phase-separation predictors currently available to demonstrate their overlapping and unique predictions and to highlight the need for second-generation predictors that would more comprehensively incorporate the multiple features associated with phase separation.

PMID:
31252218
DOI:
10.1016/j.sbi.2019.05.016

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