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Hepatology. 2019 Jun 27. doi: 10.1002/hep.30835. [Epub ahead of print]

Reply to Letters to the Editor: Diverging Definitions and Dividing Lines in Acute-on-Chronic Liver Failure.

Author information

1
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
2
Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.
3
Division of Digestive Diseases, Yale University School of Medicine, New Haven, CT.
4
VA Connecticut Healthcare System, West Haven, CT.
5
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Abstract

We appreciate the interest in our manuscript evaluating and comparing the characteristics of Asian Pacific Association for the Study of the Liver (APASL) acute-on-chronic liver failure (ACLF) and European Association for the Study of the Liver (EASL) ACLF definitions in a large cohort of diverse patients with chronic liver disease and would like to respond to several queries raised by the hepatology community. First, Choudhury et al. echo our concern that EASL ACLF, which provides multiple pathways to meet criteria based on organ failures (OFs), is nonspecific and identifies many patients with high-mortality events who ultimately die with near-normal liver labs. This article is protected by copyright. All rights reserved.

PMID:
31243784
DOI:
10.1002/hep.30835

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