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J Physiol. 2019 Jun 22. doi: 10.1113/JP276524. [Epub ahead of print]

STIM calcium sensing and conformational change.

Author information

1
Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.
2
Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, Brasil.
3
Program in Immunology, University of California-San Diego, La Jolla, CA, 92037, USA.
4
Moores Cancer Center, University of California-San Diego, La Jolla, CA, 92093, USA.

Abstract

The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM.

KEYWORDS:

ORAI; STIM; calcium; conformational change; store depletion

PMID:
31228261
DOI:
10.1113/JP276524

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