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Acta Crystallogr D Struct Biol. 2019 Jun 1;75(Pt 6):528-535. doi: 10.1107/S2059798319006880. Epub 2019 May 28.

CM01: a facility for cryo-electron microscopy at the European Synchrotron.

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European Synchrotron Radiation Facility, 71 Avenue des Martyrs, 38042 Grenoble, France.
Institut de Biologie Structurale (IBS), Université Grenoble Alpes, CNRS, CEA, 71 Avenue des Martyrs, 38042 Grenoble, France.
European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, 38042 Grenoble, France.


Recent improvements in direct electron detectors, microscope technology and software provided the stimulus for a `quantum leap' in the application of cryo-electron microscopy in structural biology, and many national and international centres have since been created in order to exploit this. Here, a new facility for cryo-electron microscopy focused on single-particle reconstruction of biological macromolecules that has been commissioned at the European Synchrotron Radiation Facility (ESRF) is presented. The facility is operated by a consortium of institutes co-located on the European Photon and Neutron Campus and is managed in a similar fashion to a synchrotron X-ray beamline. It has been open to the ESRF structural biology user community since November 2017 and will remain open during the 2019 ESRF-EBS shutdown.


CM01; ESRF; PSB; cryo-EM platform; cryo-TEM

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