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Acta Crystallogr D Struct Biol. 2019 Jun 1;75(Pt 6):528-535. doi: 10.1107/S2059798319006880. Epub 2019 May 28.

CM01: a facility for cryo-electron microscopy at the European Synchrotron.

Author information

1
European Synchrotron Radiation Facility, 71 Avenue des Martyrs, 38042 Grenoble, France.
2
Institut de Biologie Structurale (IBS), Université Grenoble Alpes, CNRS, CEA, 71 Avenue des Martyrs, 38042 Grenoble, France.
3
European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, 38042 Grenoble, France.

Abstract

Recent improvements in direct electron detectors, microscope technology and software provided the stimulus for a `quantum leap' in the application of cryo-electron microscopy in structural biology, and many national and international centres have since been created in order to exploit this. Here, a new facility for cryo-electron microscopy focused on single-particle reconstruction of biological macromolecules that has been commissioned at the European Synchrotron Radiation Facility (ESRF) is presented. The facility is operated by a consortium of institutes co-located on the European Photon and Neutron Campus and is managed in a similar fashion to a synchrotron X-ray beamline. It has been open to the ESRF structural biology user community since November 2017 and will remain open during the 2019 ESRF-EBS shutdown.

KEYWORDS:

CM01; ESRF; PSB; cryo-EM platform; cryo-TEM

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