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Brain Behav. 2019 Jul;9(7):e01286. doi: 10.1002/brb3.1286. Epub 2019 Jun 14.

Genetic association analysis of 5-HTR2A gene variants in eating disorders in a Mexican population.

Author information

1
Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México.
2
División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.
3
Hospital General de Yajalón "Manuel Velazco Suarez", Secretaría de Salud, Yajalón, Chiapas, México.
4
División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
5
Hospital Psiquiátrico Infantil Juan N Navarro, Secretaría de Salud, Ciudad de México, México.
6
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, México.

Abstract

INTRODUCTION:

The 5-HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5-HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5-HTR2A gene were associated with comorbidities in eating behavior.

METHODS:

We conducted a case-control analysis with 460 subjects. We included 168 patients with eating disorders and 292 controls; two polymorphisms of 5-HTR2A gene were genotyped. We assessed the association by allele, genotype, and inheritance models. Psychiatric comorbidities were analyzed by genotype in patients with eating disorders.

RESULTS:

We found an association between rs6311 and eating disorders in a Mexican population by allele (OR = 8.09; 95% CI = 5.99-11.03; p = 2.2e-16) and genotype (OR = 76.14; 95% CI = 35.61-177.18; p = 2.2e-16). Individuals who carried GG genotype showed increased risk for suicide attempted (OR = 2.14; CI = 1.10-4.26; p = 0.035) as comorbidity associated with eating disorders. No positive associations were observed for rs6313 polymorphism.

CONCLUSION:

Our results showed an association of rs6311 (A1438G) polymorphism of 5-HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311.

KEYWORDS:

5HTR2A gene; Gene; Mexican population; Serotonin

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