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Cell Stem Cell. 2019 Jun 6;24(6):837-838. doi: 10.1016/j.stem.2019.05.007.

Breakthrough Moments: Yoshiki Sasai's Discoveries in the Third Dimension.

Author information

1
Child Study Center, Yale University, New Haven, CT 06520, USA.
2
Child Study Center, Yale University, New Haven, CT 06520, USA; Department of Neuroscience, Yale University, New Haven, CT 06520, USA. Electronic address: flora.vaccarino@yale.edu.

Abstract

Yoshiki Sasai pioneered the organoid field with his idea of mimicking embryonic development in 3D. We shine a spotlight on his seminal work describing how the innate ability of embryonic stem cells to self-organize into layers and grow in a polarized fashion fosters their appropriate differentiation and response to morphogens.

PMID:
31173711
DOI:
10.1016/j.stem.2019.05.007

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