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Curr Issues Mol Biol. 2019 Jun 5;32:327-376. doi: 10.21775/cimb.032.327. [Epub ahead of print]

Application of Omics and Bioinformatics Tools in Streptococcus Research.

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State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, China.
Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.


Researchers used to focus on analyzing single gene or protein expression of the microbes. But recently, genome, transcriptome, proteome and metabolome have gained more and more attention. Based on technologies of omics, including genomics, transcriptomics and metabolomics, a large quantity of information about cells, microbes and human, such as the information about phylogeny, virulence, antibiotic resistance and other aspects, has been revealed. Genus Streptococcus is one of the most invasive groups of bacteria that cause both human and animal diseases, threatening public health. In this review, we summarize the application of omics to analyze this genus-Streptococcus.


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