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Neurocase. 2019 Jun - Aug;25(3-4):98-105. doi: 10.1080/13554794.2019.1625929. Epub 2019 Jun 4.

Distinguishing logopenic from semantic & nonfluent variant primary progressive aphasia: Patterns of linguistic and behavioral correlations.

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a Department of Neurology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
b Department of Cognitive Science , Krieger School of Arts and Sciences, Johns Hopkins University , Baltimore , MD , USA.
c Department of Physical Medicine and Rehabilitation , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
d Department of Otolaryngology-Head and Neck Surgery , Johns Hopkins University School of Medicine , Baltimore , MD , USA.


While language characteristics of logopenic variant primary progressive aphasia (lvPPA) are well-defined, behavioral characteristics are less understood. We investigated correlations between language and behavioral scores across three variants of primary progressive aphasia (PPA) and found language performance and behavioral disturbances are correlated in lvPPA, but not other PPA subtypes. Results suggest that unlike other PPA variants, patients diagnosed with lvPPA do not develop negative behaviors until language deficits are severe. This is consistent with the underlying neuropathology of lvPPA, Alzheimer's Disease. Such findings are crucial to clinical prognosis, especially when considering the progressive nature of this disease.


Primary progressive aphasia; behavior; language symptoms; logopenic variant primary progressive aphasia; nonfluent agrammatic primary progressive aphasia; semantic variant primary progressive aphasia

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