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Reprod Toxicol. 2019 Aug;87:100-107. doi: 10.1016/j.reprotox.2019.05.064. Epub 2019 May 30.

Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise trophoblast-endometrium cross-talk.

Author information

1
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA. Electronic address: naveennk@uw.edu.
2
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
3
Division of Reproductive Sciences, School of Medicine, Yale University, New Haven, CT 06520, USA.
4
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA. Electronic address: qmao@uw.edu.

Abstract

Marijuana (cannabis) use by pregnant women in the United States is increasing and there is a dire need to understand the beneficial or harmful effects of cannabis during pregnancy. Uterine endometrial stromal cells are fibroblast-like cells that differentiate into secretory cells, a process called decidualization, to create a microenvironment conducive for placenta formation and early embryonic growth. In this study, using model human cell lines, we for the first time demonstrate that Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) inhibit endometrial stromal cell decidualization and have adverse effects on trophoblast-endometrium cross-talk.

KEYWORDS:

CBD; Cannabinoids; Decidua; Decidualization; Embryo; Endometrial stromal cells; Fertility; Marijuana; Medicine; Reproduction; THC; Trophoblast-endometrium cross-talk models

PMID:
31154070
PMCID:
PMC6613995
[Available on 2020-08-01]
DOI:
10.1016/j.reprotox.2019.05.064

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