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Endocr Rev. 2019 Oct 1;40(5):1187-1206. doi: 10.1210/er.2018-00138.

Bone Marrow Adiposity: Basic and Clinical Implications.

Author information

1
Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
2
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut.
3
Maine Medical Center Research Institute, Scarborough, Maine.
4
Orentreich Foundation for the Advancement of Science, Cold Spring, New York.
5
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut.
6
Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Abstract

The presence of adipocytes in mammalian bone marrow (BM) has been recognized histologically for decades, yet, until recently, these cells have received little attention from the research community. Advancements in mouse transgenics and imaging methods, particularly in the last 10 years, have permitted more detailed examinations of marrow adipocytes than ever before and yielded data that show these cells are critical regulators of the BM microenvironment and whole-body metabolism. Indeed, marrow adipocytes are anatomically and functionally separate from brown, beige, and classic white adipocytes. Thus, areas of BM space populated by adipocytes can be considered distinct fat depots and are collectively referred to as marrow adipose tissue (MAT) in this review. In the proceeding text, we focus on the developmental origin and physiologic functions of MAT. We also discuss the signals that cause the accumulation and loss of marrow adipocytes and the ability of these cells to regulate other cell lineages in the BM. Last, we consider roles for MAT in human physiology and disease.

PMID:
31127816
PMCID:
PMC6686755
[Available on 2020-10-01]
DOI:
10.1210/er.2018-00138

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