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Trends Biochem Sci. 2019 May 8. pii: S0968-0004(19)30086-6. doi: 10.1016/j.tibs.2019.04.006. [Epub ahead of print]

Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.

Author information

1
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
2
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: brandt.eichman@vanderbilt.edu.

Abstract

The base excision repair (BER) pathway historically has been associated with maintaining genome integrity by eliminating nucleobases with small chemical modifications. In the past several years, however, BER was found to play additional roles in genome maintenance and metabolism, including sequence-specific restriction modification and repair of bulky adducts and interstrand crosslinks. Central to this expanded biological utility are specialized DNA glycosylases - enzymes that selectively excise damaged, modified, or mismatched nucleobases. In this review we discuss the newly identified roles of the BER pathway and examine the structural and mechanistic features of the DNA glycosylases that enable these functions.

KEYWORDS:

DNA damage; DNA glycosylase; DNA repair; base excision repair; interstrand crosslink; secondary metabolite

PMID:
31078398
DOI:
10.1016/j.tibs.2019.04.006

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