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Trends Immunol. 2019 Jun;40(6):463-465. doi: 10.1016/j.it.2019.04.004. Epub 2019 May 6.

Monocytes Inadequately Fill In for Meningeal Macrophages.

Author information

1
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.
2
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: akiko.iwasaki@yale.edu.

Abstract

In the meninges, a unique subset of tissue-resident macrophages serves as a sentinel population against invading microorganisms while suppressing harmful inflammation. A recent report shows that when murine meningeal macrophages are killed by viruses, circulating monocytes repopulate the open niche. However, they fail to mimic all aspects of tissue-resident macrophages.

PMID:
31072686
DOI:
10.1016/j.it.2019.04.004

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