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Trends Microbiol. 2019 Jun;27(6):473-475. doi: 10.1016/j.tim.2019.04.001. Epub 2019 May 2.

Host Genetics, Diet, and Microbiome: The Role of AMY1.

Author information

1
Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City 03940, Mexico; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.
2
Laboratorio de Enfermedades Cardiovasculares, INMEGEN, Mexico City 14610, Mexico.
3
Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico. Electronic address: cani@unam.mx.

Abstract

Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. (Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function. Complex genetics-diet-microbiome interactions and their effect on obesity could eventually translate into personalized nutrition.

KEYWORDS:

amylase gene; diet; microbiome

PMID:
31056302
DOI:
10.1016/j.tim.2019.04.001

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