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J Phys Chem Lett. 2019 May 16;10(10):2624-2628. doi: 10.1021/acs.jpclett.9b01091. Epub 2019 May 8.

Terahertz Spectroscopy of Tetrameric Peptides.

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Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
Energy Sciences Institute , Yale University , West Haven , Connecticut 06516 , United States.


Determining the sequence and structure of peptides is crucial for understanding their structure-property relationships. Among many techniques, structures are typically elucidated using nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction measurements. In this study, we present terahertz time-domain spectroscopy (THz-TDS) as a complementary, nondestructive technique that is sensitive to both the primary and secondary structures of tetrapeptides. Using only a few milligrams of peptide, THz-TDS spectra have been measured, some of which have been supported by density functional theory (DFT) calculations, to distinguish six tetrameric peptides with similar primary and secondary structures.

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