Send to

Choose Destination
Trends Mol Med. 2019 Mar 6. pii: S1471-4914(19)30043-7. doi: 10.1016/j.molmed.2019.02.008. [Epub ahead of print]

Cheating Death: New Molecules Block BAX.

Author information

Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:


BAX is a formidable BCL-2 family protein that executes cellular suicide in response to physiologic and pathologic stress. A new article in Nature Chemical Biology (Garner et al. reports small molecules that inhibit the conformational activation of BAX, informing a pharmacologic approach to blocking unwanted cell death in human disease.


BAX; BCL-2 family; apoptosis; inhibitor; small molecule

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center