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Trends Mol Med. 2019 Mar 6. pii: S1471-4914(19)30043-7. doi: 10.1016/j.molmed.2019.02.008. [Epub ahead of print]

Cheating Death: New Molecules Block BAX.

Author information

1
Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: loren_walensky@dfci.harvard.edu.

Abstract

BAX is a formidable BCL-2 family protein that executes cellular suicide in response to physiologic and pathologic stress. A new article in Nature Chemical Biology (Garner et al.https://doi.org/10.1038/s41589-018-0223-0) reports small molecules that inhibit the conformational activation of BAX, informing a pharmacologic approach to blocking unwanted cell death in human disease.

KEYWORDS:

BAX; BCL-2 family; apoptosis; inhibitor; small molecule

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