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PET Clin. 2019 Apr;14(2):211-221. doi: 10.1016/j.cpet.2018.12.003. Epub 2019 Feb 1.

PET-Based Imaging of Ischemic Heart Disease.

Author information

1
Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
2
Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA. Electronic address: Mehran.Sadeghi@yale.edu.

Abstract

PET-based cardiac nuclear imaging plays a large role in the management of ischemic heart disease. Compared with conventional single-photon emission CT myocardial perfusion imaging, PET provides superior accuracy in diagnosis of coronary artery disease and, with the incorporation of myocardial blood flow and coronary flow reserve, adds value in assessing prognosis for established coronary and microvascular disease. This review describes these and other uses of PET in ischemic heart disease, including assessing myocardial viability in ischemic cardiomyopathy. Developments in novel PET flow tracers and molecular imaging tools to assess atherosclerotic plaque vulnerability, vascular calcification, and vascular remodeling also are described.

KEYWORDS:

Coronary artery disease; Coronary flow reserve; Molecular imaging; Myocardial perfusion imaging; Myocardial viability; PET/CTA hybrid imaging

PMID:
30826019
PMCID:
PMC6426655
[Available on 2020-04-01]
DOI:
10.1016/j.cpet.2018.12.003
[Indexed for MEDLINE]

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