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Sci Rep. 2019 Feb 26;9(1):2748. doi: 10.1038/s41598-019-39145-x.

Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study.

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Unidad de Medicina Genómica, Hospital General de México, México City, Mexico.
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Fundación Carlos Slim, México City, Mexico.
Patia Biopharma, Mexico City, Mexico.
Huella Génica, Mexico City, Mexico.
Unidad de Medicina Genómica, Hospital General de México, México City, Mexico.
Servicio de Genética, Hospital General de México, Mexico City, Mexico.
Unidad de Investigación Médica en Bioquímica Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Méxicano del Seguro Social, Mexico City, Mexico.
Fundación Carlos Slim, México City, Mexico.


Obesity, parental history (PH) of type 2 diabetes (T2D), and genes play an important role in T2D development. However, the influence of each factor on T2D variability is unclear. This study aimed to investigate the influence of obesity (body mass index [BMI], waist/hip ratio), PH, and 16 single-nucleotide polymorphisms (SNPs) associated with T2D on T2D variability in Mexico, comparing 1234 non-diabetic controls and 1219 diabetic patients. To replicate the data, a case-control (n = 2904) and a cross-sectional (n = 1901) study were also included. In a multivariate logistic regression model, all factors accounted for only 27.3% of T2D variability: SNPs (8.4%); PH (11.8%) and obesity (7.1%). These factors contributed more in men (33.2%) than in women (25%), specifically when the disease was diagnosed before the age of 46 (46.7% vs. 30%). Genes played a substantially more important role in men than in women (14.9% vs. 5.5%), while obesity and PH played a similar role in both genders. Genes and PH appeared to play a greater role than obesity in T2D. However, obesity contribution was calculated at the time of recruitment and may be underestimated in patients because the BMI decreased linearly with the number of years with the disease. The data suggest that sexual hormones may play important roles in genes that are associated with T2D.

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