Format

Send to

Choose Destination
Int J Mol Sci. 2019 Feb 9;20(3). pii: E735. doi: 10.3390/ijms20030735.

Long Non-Coding RNA and Acute Leukemia.

Author information

1
Programa de Doctorado, Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. gmcm611@hotmail.com.
2
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico. ahidalgo@inmegen.gob.mx.
3
Programa de Doctorado, Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. d.a.barcenas@outlook.com.
4
Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. jcarlos_nu@hotmail.com.
5
Unidad de Investigación en Enfermedades Metabólicas y Endócrinas, Hospital Juárez de México, Mexico City 07760, Mexico. dr.julian.ramirez.hjm@gmail.com.
6
Coordinación de Investigación en Salud, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. juan.mejiaa@imss.gob.mx.
7
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico. sjimenez@inmegen.gob.mx.

Abstract

Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.

KEYWORDS:

acute leukemia; cancer; long non-coding RNAs; therapeutic targets

PMID:
30744139
PMCID:
PMC6387068
DOI:
10.3390/ijms20030735
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center