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Nat Med. 2019 Feb;25(2):206-211. doi: 10.1038/s41591-019-0345-2. Epub 2019 Feb 6.

Precision epidemiology for infectious disease control.

Author information

1
Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
2
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
3
Department of Zoology, University of Oxford, Oxford, UK.
4
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. andersen@scripps.edu.
5
Scripps Research Translational Institute, La Jolla, CA, USA. andersen@scripps.edu.

Abstract

Advances in genomics and computing are transforming the capacity for the characterization of biological systems, and researchers are now poised for a precision-focused transformation in the way they prepare for, and respond to, infectious diseases. This includes the use of genome-based approaches to inform molecular diagnosis and individual-level treatment regimens. In addition, advances in the speed and granularity of pathogen genome generation have improved the capability to track and understand pathogen transmission, leading to potential improvements in the design and implementation of population-level public health interventions. In this Perspective, we outline several trends that are driving the development of precision epidemiology of infectious disease and their implications for scientists' ability to respond to outbreaks.

PMID:
30728537
DOI:
10.1038/s41591-019-0345-2

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