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J Enzyme Inhib Med Chem. 2019 Dec;34(1):613-619.

Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4+ cells.

Author information

1
a Department of Physical Education, College of Education , Daegu Catholic University , Gyeongsan , Republic of Korea.
2
b Natural Product Material Research Center, Korea Research Institute of Bioscience and Biotechnology , Jeongeup , Republic of Korea.
3
c Division of Food Bioscience, College of Biomedical and Health Sciences , Konkuk University , Chungju , Republic of Korea.
4
d Changchun University of Science and Technology , Changchun , China.
5
e Department of Food Science and Biotechnology , Dongguk University , Goyang , Republic of Korea.
6
f College of Pharmacy , Keimyung University , Daegu , Republic of Korea.

Abstract

This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum immunoglobulin (Ig) levels and expression of T-helper (Th)1/Th2 cytokines. Moreover, cinnamamides suppressed interleukin (IL)-4, which plays a crucial role in preparing naïve clusters of differentiation (CD)4+ T cells, and decreased the cervical lymph node size and weight. Interestingly, in almost all cases, NCPA exhibited higher anti-AD activity compared to NCT. These results strongly indicate that NCPA may have potential as an anti-AD agent, and further mechanistic comparative studies of NCT and NCPA are required to determine the cause of differences in biological activity.

KEYWORDS:

Atopic dermatitis; CD4+ T cells; IL-4; Th1/Th2 cytokines; cinnamamides

PMID:
30727775

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