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Trends Immunol. 2019 Mar;40(3):175-177. doi: 10.1016/j.it.2019.01.009. Epub 2019 Jan 31.

Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity.

Author information

1
Department of Molecular, Cell and Developmental Biology, Yale University, 219 Prospect St., Box 208103, New Haven, CT 06520, USA.
2
Department of Molecular, Cell and Developmental Biology, Yale University, 219 Prospect St., Box 208103, New Haven, CT 06520, USA. Electronic address: valerie.horsley@yale.edu.

Abstract

In a recent study, Zhang et al. (Immunity 2019;50:121-136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors.

KEYWORDS:

TGF-β; adipocyte; aging; bacterial infection; fibroblast

PMID:
30713009
DOI:
10.1016/j.it.2019.01.009

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