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Pigment Cell Melanoma Res. 2019 May;32(3):458-469. doi: 10.1111/pcmr.12771. Epub 2019 Feb 19.

Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.

Author information

1
Moffitt Cancer Center, Tampa, Florida.
2
University of Utah Health Sciences Center, Salt Lake City, Utah.
3
The Wistar Institute, Philadelphia, Pennsylvania.
4
The University of Pennsylvania, Philadelphia, Pennsylvania.
5
Stanford University, Palo Alto, California.
6
MD Anderson Cancer Center, Houston, Texas.
7
Northwestern University, Chicago, Illinois.
8
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
9
Yale University, New Haven, Connecticut.
10
Georgetown University Cancer Center, Washington, District of Columbia.
11
City of Hope, Duarte, California.

Abstract

In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area.

KEYWORDS:

brain metastases; immunotherapy; melanoma; metastasis; targeted therapy

PMID:
30712316
DOI:
10.1111/pcmr.12771
[Indexed for MEDLINE]

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