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J Affect Disord. 2019 Feb 15;245:861-868. doi: 10.1016/j.jad.2018.11.080. Epub 2018 Nov 13.

Intrinsic brain abnormalities in drug-naive patients with obsessive-compulsive disorder: A resting-state functional MRI study.

Author information

1
Mental Health Center, Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China; Shenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen, China.
2
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
3
Mental Health Center, Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
4
Mental Health Center, Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China. Electronic address: yanchunyang1958@sina.com.
5
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: qiyonggong@hmrrc.org.cn.
6
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: julianahuang@163.com.

Abstract

BACKGROUND:

Using the resting-state functional magnetic resonance imaging (rs-fMRI) in a relatively large sample of drug-naive patients with obsessive-compulsive disorder (OCD), the current study aims to explore alterations in regional and network-level neural function and to determine the association between these alterations in intrinsic neural activity and symptom severity in OCD.

METHODS:

A total of 68 drug-naive OCD patients and 68 healthy control subjects (HCS) were examined using rs-fMRI. Regional cerebral function was evaluated by measuring the fraction of amplitude of low-frequency fluctuation (fALFF). Regions with fALFF alterations were used as seeds in whole-brain functional connectivity (FC) analysis. Statistical analyses of fALFF and FC differences between OCD patients with HCS were performed voxel-by-voxel using a two-sample t-test in Statistical Parametric Mapping version 8 (SPM8). Whole brain correlation analyses were performed to identify the association between functional neural correlates and OCD symptom severity evaluated using Yale-Brown Obsessive Compulsive scale (Y-BOCS) and subscale scores.

RESULTS:

Relative to HCS, OCD patients showed higher fALFF in the right putamen and right superior frontal gyrus (P < 0.05, corrected for AlphaSim); higher FC in the limbic-striatal circuit and lower FC in the fronto-temporal and fronto-striato-thalamic networks (P < 0.05, corrected for AlphaSim). FC in striato-thalamic junction was negatively correlated with the Y-BOCS total score (r = -0.493, P < 0.001).

CONCLUSION:

These findings of focal spontaneous hyperfunction confirmed the prevailing frontal-striatal model of OCD, and altered brain connectivity in large-scale resting-state networks indicated a connectivity-based pathophysiological process in OCD.

KEYWORDS:

Drug-naive; Fractional amplitude of low-frequency fluctuation; Functional connectivity; Obsessive-compulsive disorder; Resting-state fMRI

PMID:
30699871
DOI:
10.1016/j.jad.2018.11.080
[Indexed for MEDLINE]

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