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J Infect Dis. 2019 Jan 24. doi: 10.1093/infdis/jiz002. [Epub ahead of print]

Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi.

Author information

1
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre.
2
Medical Laboratory Department, College of Medicine, University of Malawi, Blantyre.
3
Centre for Global Vaccine Research, Institute of Infection & Global Health, Liverpool.
4
National Institute for Health Research Health Protection Research Unit in Gastrointestinal Infections, University of Liverpool, United Kingdom.
5
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
6
Division of Infection and Immunity, University College London, United Kingdom.
7
MRC Centre for Inflammation Research, University of Edinburgh, United Kingdom.
8
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut.
9
Centers for Disease Control and Prevention, Atlanta, Georgia.
10
Department of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Abstract

Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8-10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.

PMID:
30689911
DOI:
10.1093/infdis/jiz002

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