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J Infect Dis. 2019 May 24;219(12):1959-1962. doi: 10.1093/infdis/jiz023.

DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection.

Author information

1
Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta.
2
Department Global Health, Emory University Rollins School of Public Health, Atlanta.
3
Division of Infectious Diseases, Emory University School of Medicine, Atlanta.
4
Department of Biomedical Informatics, Emory University School of Medicine, Atlanta.
5
Atlanta Veterans Affairs Medical Center, Georgia.
6
Boston University School of Medicine, Massachusetts.
7
Cardiovascular Medicine Division, Vanderbilt University School of Medicine and Tennessee Valley Healthcare System, Nashville.
8
Connecticut Veteran Health System, West Haven.
9
Department of Psychiatry, New Haven, Connecticut.
10
Yale School of Medicine, New Haven, Connecticut.

Abstract

Epigenetic modifications such as DNA methylation are associated with both human immunodeficiency virus (HIV) infection and type 2 diabetes mellitus (T2DM). We investigated epigenetic associations with T2DM according to HIV infection status and assessed interaction effects among 681 male participants of the Veterans Aging Cohort Study. Methylation at previously reported sites, cg1963031 (TXNIP), cg18181703 (SOCS3), and cg09152259 (PROC), was significantly associated with T2DM in HIV-infected individuals. We identified 3 novel associations with suggestive statistical significance: cg1231141 (ADAMTS2), cg19534769 (HGFAC), and cg13163919 (TLE3). Suggestive interaction with HIV infection status was found at cg17862404 (TSC22D1). The implicated genes are involved in inflammation, pancreatic β-cell function, and T2DM pathogenesis.

KEYWORDS:

DNA methylation; HIV; Type 2 Diabetes; epigenome

PMID:
30649532
PMCID:
PMC6534194
[Available on 2020-05-24]
DOI:
10.1093/infdis/jiz023

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