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J Cell Physiol. 2019 Apr;234(4):3661-3674. doi: 10.1002/jcp.27135. Epub 2018 Sep 14.

Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis.

Author information

1
Deparment of Pharmacology of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
2
The Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
3
Department of Chemical Research and Structural Optimization based on Chinese Material Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
4
The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
5
Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
6
Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Abstract

Psoriasis is a common chronic skin disease characterized by epidermal hyperplasia and inflammation. However, the pathogenesis of psoriasis is multifactorial and is not fully understood. MicroRNAs (miRNAs) represent a promising class of small, noncoding RNA molecules that have a large impact on cellular functions by regulating gene expression. Here we reported that microRNA-187 (miR-187), which is one of the most dynamic microRNAs identified in the deep screening miRNAs profile, is downregulated in inflammatory cytokines-stimulated keratinocytes and psoriatic skins. By luciferase activity assay and gain-of-function studies, we showed that miR-187 inhibits keratinocytes hyperproliferation by targeting CD276. Moreover, overexpression of miR-187 decreases acanthosis and reduces the disease severity in psoriasis mouse models. Taken together, the results of our study implies miR-187 as a critical factor in psoriasis pathogenesis, which could be a potent target for psoriasis treatment.

KEYWORDS:

CD276; epidermal hyperplasia; keratinocytes hyperproliferation; microRNA‐187 (miR‐187); psoriasis

PMID:
30607907
DOI:
10.1002/jcp.27135

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