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Annu Rev Biochem. 2019 Jun 20;88:691-724. doi: 10.1146/annurev-biochem-013118-111153. Epub 2019 Jan 11.

Mechanism and Regulation of Centriole and Cilium Biogenesis.

Author information

1
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA; email: david.breslow@yale.edu.
2
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; email: aholland@jhmi.edu.

Abstract

The centriole is an ancient microtubule-based organelle with a conserved nine-fold symmetry. Centrioles form the core of centrosomes, which organize the interphase microtubule cytoskeleton of most animal cells and form the poles of the mitotic spindle. Centrioles can also be modified to form basal bodies, which template the formation of cilia and play central roles in cellular signaling, fluid movement, and locomotion. In this review, we discuss developments in our understanding of the biogenesis of centrioles and cilia and the regulatory controls that govern their structure and number. We also discuss how defects in these processes contribute to a spectrum of human diseases and how new technologies have expanded our understanding of centriole and cilium biology, revealing exciting avenues for future exploration.

KEYWORDS:

cell cycle; centriole; centrosome; cilia; ciliopathy; mitosis

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