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Cell Mol Gastroenterol Hepatol. 2019;7(3):503-513. doi: 10.1016/j.jcmgh.2018.12.002. Epub 2018 Dec 14.

The Intestinal Lymphatic System: Functions and Metabolic Implications.

Author information

1
Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri. Electronic address: cifarelli@wustl.edu.
2
Cardiovascular Research Center and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut; INSERM U970, Paris Cardiovascular Research Center, Paris, France.

Abstract

The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial functions in intestinal homeostasis, the lymphatic system has been poorly studied. In the last 2 decades, identification of specific molecular mediators of lymphatic endothelial cells (LECs) growth together with novel genetic approaches and intravital imaging techniques, have advanced our understanding of the mechanisms regulating intestinal lymphatic physiology in health and disease. As its metabolic implications are gaining recognition, intestinal lymphatic biology is currently experiencing a surge in interest. This review describes current knowledge related to molecular control of intestinal lymphatic vessel structure and function. We discuss regulation of chylomicron entry into lymphatic vessels by vascular endothelial growth factors (VEGFs), hormones, transcription factors and the specific signaling pathways involved. The information covered supports the emerging role of intestinal lymphatics in etiology of the metabolic syndrome and their potential as a therapeutic target.

KEYWORDS:

Endothelium; Lacteals; Lipid; Obesity; VEGF Signaling

PMID:
30557701
PMCID:
PMC6396433
DOI:
10.1016/j.jcmgh.2018.12.002
[Indexed for MEDLINE]
Free PMC Article

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