Format

Send to

Choose Destination
J Child Neurol. 2018 Dec 17:883073818815041. doi: 10.1177/0883073818815041. [Epub ahead of print]

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

Author information

1
1 Pediatric Multiple Sclerosis Center at Loma Linda University Children's Hospital, Loma Linda, CA, USA.
2
2 Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
3
3 Pediatric Multiple Sclerosis Program, Columbia University Medical Center, New York, NY, USA.
4
4 Pediatric Multiple Sclerosis Program, Yale MS and Neuroimmunology Center, New Haven, CT, USA.
5
5 Center for Pediatric-Onset Demyelinating Disease at the Children's Hospital of Alabama, Birmingham, AL, USA.
6
6 Pediatric Multiple Sclerosis and Related Disorders Program at Boston Children's Hospital, Boston, MA, USA.
7
7 Partners Pediatric Multiple Sclerosis Center at the Massachusetts General Hospital for Children, Boston, MA, USA.
8
8 Neurology, University of California, San Francisco, CA, USA.
9
9 University of Texas Southwestern, Dallas, TX, USA.
10
10 The Blue Bird Circle Clinic for Multiple Sclerosis, Texas Children's Hospital, Houston, TX, USA.
11
11 Washington University Pediatric Multiple Sclerosis and other Demyelinating Disease Center, St. Louis, MO, USA.
12
12 Mayo Clinic Pediatric Multiple Sclerosis Center, Rochester, MN, USA.
13
13 Cleveland Clinic, Cleveland, OH, USA.
14
14 Lurie Children's Hospital, Chicago, IL, USA.
15
15 Rocky Mountain Multiple Sclerosis Center, University of Colorado at Denver, Aurora, CO, USA.
16
16 The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
17
17 Pediatric Multiple Sclerosis Center of the Jacobs Neurological Institute, Buffalo, NY, USA.
18
18 Stony Brook University, Stony Brook, New York, NY, USA.
19
19 Pediatric Multiple Sclerosis Center at New York University Langone Medical Center, New York, NY, USA.

Abstract

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric multiple sclerosis (n = 467) were not delayed in walking or using 2-word phrases compared to healthy controls (n = 428) (2.2% vs 5.7%, respectively). Children with disease onset before age 11 versus onset at 11 years or after were more likely to need an individualized education plan ( P = .002), reading assistance ( P = .0003), and math assistance ( P = .001). Children with multiple sclerosis onset prior to age 18 are not delayed in meeting the 2 major early developmental milestones but do have a significantly increased use of special services or learning assistance at school. Further research will need to address whether other measures of development (eg, rate of language acquisition or fine motor skills) differ between pediatric multiple sclerosis and controls.

KEYWORDS:

cognitive impairment; developmental milestones; multiple sclerosis; pediatric

PMID:
30556452
PMCID:
PMC6579723
[Available on 2020-06-17]
DOI:
10.1177/0883073818815041

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center