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J Biol Chem. 2018 Dec 7;293(49):19157-19158. doi: 10.1074/jbc.H118.006600.

Genetic code and metabolism: The perpetual waltz.

Author information

1
From the Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Parc Científic de Barcelona, C/Baldiri Reixac 10, 08028 Barcelona, Catalonia, Spain and Catalan Institution for Research and Advanced Studies (ICREA), P/Lluís Companys 23, 08010 Barcelona, Catalonia, Spain lluis.ribas@irbbarcelona.org.

Abstract

Since the origin of life, metabolism and protein synthesis have evolved together to balance the vast amounts of ATP and amino acids required for genetic translation with the rest of the cell's energy needs. A new study offers satisfying insights into a long-standing evolutionary mystery surrounding a fused, bifunctional aminoacyl-tRNA synthetase. To avoid depleting cells from an essential amino acid generated by the Krebs cycle, harvesting for Glu and Pro by the translation machinery was unified in animals, thus preventing a Pro-hungry translational apparatus from depleting the cell of essential Glu reserves.

Conflict of interest statement

The author declares that he has no conflicts of interest with the contents of this article.

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