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J Bone Miner Metab. 2019 Jul;37(4):749-758. doi: 10.1007/s00774-018-0978-0. Epub 2018 Dec 4.

Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges.

Author information

1
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
2
Unidad de Investigación en Epidemiología Clínica, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
3
Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
4
Centro de Estudios de Metabolismo Fosfocálcico, Universidad Nacional de Rosario, Rosario, Argentina.
5
Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
6
Unidad Académica en Investigación Epidemiológica, Centro de Investigación en Políticas, Población y Salud, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
7
Centro de Estudios de Metabolismo Fosfocálcico, Universidad Nacional de Rosario, Rosario, Argentina. gcointry@gmail.com.
8
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.

Abstract

The present study aims: (1) to explore the influence of lean mass (LM) on bone mineral content (BMC), (2) to investigate the pubertal influences on the BMC-LM relation, and (3) to perform Z-score charts of BMC-LM relation, stratified by gender and reproductive status categorized by age ranges. A cross-sectional analysis was conducted using 4001 healthy subjects between 7 and 90 years participating in the Health Workers Cohort Study. Of these, 720 participants were ≤ 19 years, 2417 were women ≥ 20 years, and 864 were men ≥ 20 years. Using Dual X-ray absorptiometry (DXA), we measured BMC and LM. Participants' pubertal development was assessed according to Tanner's stage scale. To describe BMC-LM relation, simple correlation coefficients were computed. To produce best-fit equations, an ANOVA test was conducted. Z-score graphs for the BMC-LM relation were obtained. In general, the BMC-LM correlations were linear and highly significant. For boys, curves were virtually parallel, with similar intercepts and a progressive displacement of values toward the upper-right region of the graph, for each Tanner subgroup. For girls, curves for Tanner 1-2 and 4-5 stages were parallel; but, in girls Tanner 4-5, the intercepts were significantly higher by about +300-400 g of BMC (P < 0.001). For postmenopausal women, the curve was parallel to that for the premenopausal but showed a lower intercept (P < 0.001). We provide DXA reference data on a well-characterized cohort of 4001 healthy subjects. These reference curves provide a reference value for the assessment and monitoring of bone health in all age groups included in the present study.

KEYWORDS:

Bone mineral content; Lean mass; Muscle–bone relation; Tanner stage

PMID:
30515578
DOI:
10.1007/s00774-018-0978-0
[Indexed for MEDLINE]

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