Send to

Choose Destination
BMC Microbiol. 2018 Nov 23;18(Suppl 1):179. doi: 10.1186/s12866-018-1280-y.

Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives.

Author information

Biotechnology Research Institute, Kenya Agricultural & Livestock Research Organization, P.O Box 57811, 00200, Kaptagat Rd, Loresho, Nairobi, Kenya.
Insect Pest Control Laboratory, FAO/IAEA Agriculture & Biotechnology Laboratory, IAEA Laboratories Seibersdorf, A-2444, Seibersdorf, Austria.
Laboratory of Virology, Wageningen University and Research, Wageningen, 6708 PB, The Netherlands.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT, 06510, USA.
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
International Centre of Insect Physiology and Ecology, P.O. Box 30772, 00100, Nairobi, Kenya.
INTERTRYP, Institut de Recherche pour le Développement, University of Montpellier, Montpellier, France.
Institute of Chemical, Environmental & Biological Engineering, Research Area Biochemical Technology, Vienna University of Technology, Gumpendorfer Straße 1a, 1060, Vienna, Austria.
Department of Medical Microbiology, Acıbadem Mehmet Ali Aydınlar University, School of Medicine, 34752, Ataşehir, Istanbul, Turkey.
Centre for Biomolecular Interactions Bremen, Faculty for Biology & Chemistry, Universität Bremen, Bibliothekstraße 1, 28359, Bremen, Germany.
Laboratory of Parasitology and Ecology, Faculty of Sciences, Department of Animal Biology and Physiology, University of Yaoundé 1, Yaoundé, BP, 812, Cameroon.
Trypanosomiasis Research Centre, Kenya Agricultural & Livestock Research Organization, P.O. Box 362-00902, Kikuyu, Kenya.
Molecular Department, Vector and Vector Borne Diseases Institute, Tanzania Veterinary Laboratory Agency, Majani Mapana, Off Korogwe Road, Box, 1026, Tanga, Tanzania.
Insect Pest Control Laboratory, FAO/IAEA Agriculture & Biotechnology Laboratory, IAEA Laboratories Seibersdorf, A-2444, Seibersdorf, Austria.


With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.


Glossina; Hytrosaviridae; Microbiota; Paratransgenesis; Trypanosoma-refractoriness, sterile insect technique; Vector competence

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center