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J Dermatolog Treat. 2019 Nov;30(7):659-663. doi: 10.1080/09546634.2018.1544410. Epub 2018 Dec 2.

Patient preferences for attributes of topical anti-psoriatic medicines.

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a CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Gandra PRD , Portugal.
b UCIBIO- REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy University of Porto , Porto , Portugal.
c ISEP, Instituto Superior de Engenharia do Porto, Politécnico do Porto , Porto , Portugal.
d CEAUL, Centro de Estatística e Aplicações da Universidade de Lisboa, Faculdade de Ciências , Campo Grande , Portugal.
e Serviço de Dermatologia, Centro Hospitalar do Porto, Hospital de Santo António , Porto , Portugal.


Background: Patient preferences should be considered when prescribing topical treatments to drive up adherence and improve clinical outcomes. Objective: The aim of this work was to identify the most important attributes of topical medicines for psoriasis treatment in the patients' view, and explore the sociodemographic and clinical determinants of these preferences. Methods: A questionnaire for the evaluation of the relevancy given to specific attributes of topical medicines used for psoriasis treatment was developed (PSO-TOPAP) and was applied to a total of seventy-nine patients, members of the Portuguese Association of Psoriasis (PSOPortugal) or outpatients of a dermatology unit of a central hospital. Results: Overall, attributes belonging to the formulation and application domains were greatly valued over attributes related to the container. Only a small number of patient preferences was influenced by age, gender, duration of the disease and age at first diagnosis. Limitations: Our findings need to be verified in larger and more diverse patient samples before generalization can be made. Conclusion: The insight obtained in this work can provide guidance to pharmaceutical drug product design and has also the potential to improve patient care through the acknowledgment of patient preferences in clinical practice.


Psoriasis; adherence; patient preferences; topical treatment

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