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Genetics. 2019 Jan;211(1):201-217. doi: 10.1534/genetics.118.301704. Epub 2018 Nov 15.

The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production.

Park AR1,2, Liu N1,2, Neuenkirchen N1,2, Guo Q1,2, Lin H3,2.

Author information

1
Yale Stem Cell Center, Yale University School of Medicine, New Haven, Connecticut 06520.
2
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520.
3
Yale Stem Cell Center, Yale University School of Medicine, New Haven, Connecticut 06520 haifan.lin@yale.edu.

Abstract

Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early Drosophila embryogenesis. Maternal HP1a upregulates genes involved in translation, mRNA splicing, and cell division, but downregulates genes involved in neurogenesis, organogenesis, and germline development, which all occur later in development. Our study reveals the earliest contribution of HP1a during oogenesis in regulating the production of maternal transcripts that drive early Drosophila embryogenesis.

KEYWORDS:

HP1a; embryonic mitosis; maternal transcriptome; oogenesis

PMID:
30442760
PMCID:
PMC6325692
[Available on 2020-01-01]
DOI:
10.1534/genetics.118.301704
[Indexed for MEDLINE]

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