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Front Physiol. 2018 Oct 18;9:1487. doi: 10.3389/fphys.2018.01487. eCollection 2018.

Mitochondria, Oxidative Stress and Innate Immunity.

Author information

1
Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
2
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
3
Department of Pathology and the Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States.

Abstract

Canonical functions of mitochondria include the regulation of cellular survival, orchestration of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling. Recent discoveries, nevertheless, have demonstrated that mitochondria are also critical elements to stimulate innate immune signaling cascade that is able to intensify the inflammation upon cytotoxic stimuli beyond microbial infection. Here we review the expanding research field of mitochondria and oxidative stress in innate immune system to highlight the new mechanistic insights and discuss the pathological relevance of mitochondrial dysregulation induced aberrant innate immune responses in a growing list of sterile inflammatory diseases.

KEYWORDS:

ROS; inflammasome; innate and adaptive immune response; mitochondria; thioredoxin

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