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Chem Commun (Camb). 2018 Nov 8;54(90):12738-12741. doi: 10.1039/c8cc06725b.

From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom.

Author information

1
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, Barcelona 08028, Spain. ernest.giralt@irbbarcelona.org meritxell.teixido@irbbarcelona.org.

Abstract

The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.

PMID:
30357254
DOI:
10.1039/c8cc06725b
[Indexed for MEDLINE]

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