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Cell. 2018 Oct 18;175(3):641-642. doi: 10.1016/j.cell.2018.10.011.

Flipping ATP to AMPlify Kinase Functions.

Author information

1
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.
2
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Cancer Biology Institute, Yale University, West Haven, CT 06516, USA. Electronic address: mark.lemmon@yale.edu.

Abstract

Understanding protein kinase family members that lack key catalytic residues-or pseudokinases-is a major challenge in cell signaling. In this issue of Cell, Sreelatha et al. (2018) describe how one pseudokinase transfers adenosine monophosphate (AMP) rather than phosphate to protein substrates, revealing unexpected catalytic diversity for the kinase fold.

PMID:
30340038
PMCID:
PMC6421561
[Available on 2019-10-18]
DOI:
10.1016/j.cell.2018.10.011
[Indexed for MEDLINE]

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